Find a Clinical Trial
Browse trials that may be suitable for you, written in plain English
Keyhole vs Open Surgery for Aortic Aneurysm
For people with: Abdominal Aortic Aneurysm
This trial is comparing two types of surgery for a swelling in the main blood vessel in your abdomen (called an aortic aneurysm). We want to find out which approach leads to better long-term outcomes for patients.
You may be eligible if you are over 55 and have been diagnosed with an abdominal aortic aneurysm measuring 5.5 cm or more. Your surgeon must consider you fit enough for either type of operation.
Find out more →Surgery vs Stent Treatment for Reduced Blood Flow to the Gut
For people with: Chronic Mesenteric Ischaemia
This trial is for people who get pain after eating because of reduced blood flow to their bowel. We are comparing an operation with a less invasive stent procedure to find out which approach helps patients recover better and reduces symptoms.
You may be eligible if you have been diagnosed with reduced blood flow to your gut (chronic mesenteric ischaemia) and experience pain after eating or unexplained weight loss. Your doctor will confirm your diagnosis with a scan before discussing the trial with you.
Find out more →Longer Blood-Thinning Injections After Major Vascular Surgery
For people with: Venous Thromboembolism
After major surgery on your blood vessels, there is a risk of blood clots forming in your legs or lungs. This trial is testing whether giving blood-thinning injections for four weeks after surgery (instead of the usual shorter course) can reduce that risk.
You may be eligible if you are due to have major vascular surgery (such as an operation on the arteries in your abdomen or legs). Your surgical team will discuss the trial with you before your operation.
Find out more →Glue Treatment vs Heat Treatment for Varicose Veins
For people with: Varicose Veins / Chronic Venous Insufficiency
This trial is comparing two keyhole treatments for varicose veins. One uses a medical glue to seal the faulty vein, and the other uses heat. Both are done under local anaesthetic as a day case. We want to find out if the glue treatment works just as well as the heat treatment.
You may be eligible if you have varicose veins that are causing symptoms such as aching, swelling, or skin changes in your legs. An ultrasound scan will be used to check whether your veins are suitable for treatment in this trial.
Find out more →Combined Keyhole and Open Surgery vs Bypass Surgery for Severely Blocked Leg Arteries
For people with: Critical Limb-Threatening Ischaemia
This trial is for people with very poor blood flow in their legs because of blockages at more than one level. We are comparing a newer combined approach (part keyhole, part open surgery) with a traditional bypass operation, to see which gives better results and a faster recovery.
You may be eligible if you have severe leg pain at rest, non-healing wounds, or are at risk of losing your leg due to blocked arteries at more than one level. Your vascular surgeon will assess whether either approach is suitable for you.
Find out more →Balloon Treatment vs Medication for High Blood Pressure Caused by a Kidney Artery Problem
For people with: Renal Fibromuscular Dysplasia
This trial is for people whose high blood pressure is caused by a narrowing in one of the arteries that supplies their kidney. We are comparing a balloon procedure to widen the artery with blood pressure medication alone, to see which approach controls blood pressure better over time.
You may be eligible if you have high blood pressure that your doctor believes is caused by a condition called fibromuscular dysplasia, which narrows the artery to your kidney. You will need a scan to confirm the diagnosis.
Find out more →Comparing Two Types of Balloon Treatment for Poor Leg Circulation
For people with: Peripheral Arterial Disease
This trial is for people with very poor blood flow in their legs, which can cause pain and difficulty walking. We are comparing two types of balloon treatment to open up narrowed blood vessels — one uses a special drug coating and the other does not. We want to see which keeps the blood vessel open for longer.
You may be eligible if you have been diagnosed with severe narrowing of the arteries in your leg that is causing rest pain, ulcers, or difficulty walking short distances. Your vascular team will check whether this trial is suitable for you.
Find out more →Surgery vs Stent for a Narrowed Neck Artery After a Stroke or Mini-Stroke
For people with: Symptomatic Carotid Artery Stenosis
If you have had a stroke or mini-stroke caused by a narrowed artery in your neck, this trial is comparing two ways to treat it. One is an operation to clean out the artery, and the other is a stent (a small tube placed inside the artery to hold it open). We want to find out which gives better long-term results.
You may be eligible if you have recently had a stroke or mini-stroke and a scan has shown a significant narrowing in one of the main arteries in your neck (the carotid artery). Your stroke or vascular team will discuss whether this trial is right for you.
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